Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

Several metabolic, cardiovascular, and neurological disorders are characterized by
mitochondrial dysfunction followed by dysregulation of cellular energetics. Mitochondria play …

The NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome has been
implicated in renal inflammation and fibrosis. However, the biological function of …

Chronic inflammation in tumor microenvironment plays an important role at different stages
of tumor development. The specific mechanisms of the association and its role in providing a …

Aldosterone (Aldo) is an independent risk factor for chronic kidney disease (CKD), and
although Aldo directly induces renal tubular cell injury, the underlying mechanisms remain …

Background Regulation of cell death during neurodegeneration is one of the key factors that
play a role in the speed at which a disease progresses. Out of several cellular pathways …

Increasing evidence suggests that inflammation and apoptosis are involved in the
development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization …

Background NOD-like receptors (NLR) are intracellular sensors of the innate immune
system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia …

NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains
enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …