Statins are widely used to prevent major cardiovascular events by lowering serum
cholesterol. There is evidence that statins have pleiotropic effects—that is, cholesterol …

Background Epigenetic events involving the methylation of CpG cites in DNA, histone
modifications and noncoding RNAs correlated with many essential processes in human …

Aim Although statins are considered a cornerstone for the treatment of high cholesterol
levels due to their powerful cholesterol-lowering effects, response to drug administration is …

The current review summarizes recent experimental evidence highlighting the different
effects of statins on cellular pathways regulating gene expression. Understanding the basic …

Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and the
prevention of secondary heart attacks. Currently, available statins vary in terms of their …

Coronary artery disease (CAD) is the leading cause of death worldwide. The efficacy and
safety of statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) in primary …

Statins, besides being powerful cholesterol-lowering drugs, also exert potent anti-
proliferative activities. However, their anti-cancer efficacy differs among the individual …

Satisfying these requirements for clinical applicability will be challenging, but discovery of
specific genotypes that influence statin efficacy and characterization of their functional …

Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …

The Pharmacogenomics Journal (2006) 6, 360–374. doi: 10.1038/sj. tpj. 6500384;
published online 21 March 2006 β-hydroxy-β-methylglutaryl Coenzyme A (HMG-CoA) …