Background Citalopram is a selective serotonin reuptake inhibitor (SSRI) mainly prescribed
to treat major depression. Objective The aim of this study was to compare the …

Citalopram is commonly prescribed to patients suffering from major depressive disorder.
Some of them do not respond adequately to therapy with citalopram, while many of them …

What is known and objective There is great interindividual variability in citalopram (CIT)
pharmacokinetics. We attempted to establish a population pharmacokinetic (PPK) model of …

We investigate the impact of sex and genotype on citalopram disposition in 35 healthy
volunteers who received an oral dose of 20mg citalopram within a single-dose …

Background—Various antidepressant agents are metabolized by the CYP2C19 enzyme,
including Citalopram and Escitalopram. Variation in CYP2C19 expression might give rise to …

Background: Citalopram tablets fulfill most dosing needs in the treatment of depression, but
some patients may have difficulty swallowing tablets and thus may be less likely to comply …

Although the relationship of CYP2C19 polymorphism to citalopram disposition has been
studied in healthy subject, this relationship in combination with dynamic effects (clinical …

The study was designed to define the contribution of cytochrome P450 2C19 (CYP2C19)
and cytochrome P450 3A4 (CYP3A4) to citalopram N-demethylation and to evaluate the …

Background: Fluconazole is a triazole antifungal agent labeled for use in the treatment of
oropharyngeal and esophageal candidiasis and cryptococcal meningitis, marketed in …

A simple sensitive and robust method for simultaneous determination of citalopram and
desmethylcitalopram was developed using liquid chromatography tandem mass …