Trehalose‐6‐phosphate‐mediated phenotypic change in Acinetobacter baumannii

JJ Hubloher, S Zeidler, P Lamosa… - Environmental …, 2020 - Wiley Online Library
The stress protectant trehalose is synthesized in Acinetobacter baumannii from UPD‐
glucose and glucose‐6‐phosphase via the OtsA/OtsB pathway. Previous studies proved that …

Trehalose, a temperature‐ and salt‐induced solute with implications in pathobiology of Acinetobacter baumannii

S Zeidler, J Hubloher, K Schabacker… - Environmental …, 2017 - Wiley Online Library
Acinetobacter baumannii is an opportunistic human pathogen that has become a global
threat to healthcare institutions worldwide. A major factor contributing to success of this …

Trehalose-deficient Acinetobacter baumannii exhibits reduced virulence by losing capsular polysaccharide and altering membrane integrity

CS Crippen, J Glushka, E Vinogradov… - …, 2021 - academic.oup.com
Acinetobacter baumannii has become a leading cause of bacterial nosocomial infections, in
part, due to its ability to resist desiccation, disinfection and antibiotics. Several factors …

Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response

FS Cardoso, RF Castro, N Borges… - Microbiology, 2007 - microbiologyresearch.org
Propionibacterium freudenreichii accumulates high levels of trehalose, especially in
response to stress. The pathways for trehalose metabolism were characterized, and their …

Toluene‐induced accumulation of trehalose by Pseudomonas sp. BCNU 106 through the expression of otsA and otsB homologues

HC Park, YU Bae, SD Cho, SA Kim… - Letters in applied …, 2007 - academic.oup.com
Aim: The objective of this study was to investigate toluene‐induced accumulation
mechanism of trehalose in a toluene‐tolerant bacterium Pseudomonas sp. BCNU 106 …

Three pathways for trehalose metabolism in Corynebacterium glutamicum ATCC13032 and their significance in response to osmotic stress

A Wolf, R Krämer, S Morbach - Molecular microbiology, 2003 - Wiley Online Library
Genome scanning of Corynebacterium glutamicum ATCC13032 revealed the presence of
five different genes encoding enzymes belonging to three putative trehalose biosynthesis …

Regulation of expression of trehalose-6-phosphate synthase during cold shock in Arthrobacter strain A3

XM Chen, Y Jiang, YT Li, HH Zhang, J Li, X Chen… - Extremophiles, 2011 - Springer
Trehalose is a chemical chaperone known to protect a variety of organisms against cold
stress. Members of the genus Arthrobacter, which belongs to the Actinomycetales group …

Trehalose acts as a uridine 5′‐diphosphoglucose‐competitive inhibitor of trehalose 6‐phosphate synthase in Corynebacterium glutamicum

S Oide, M Inui - The FEBS Journal, 2017 - Wiley Online Library
Trehalose is a compatible solute widely distributed in nature. The most prevalent pathway
for its synthesis starts from condensation of glucose 6‐phosphate (Glc6P) and uridine 5 …

[HTML][HTML] A trehalose biosynthetic enzyme doubles as an osmotic stress sensor to regulate bacterial morphogenesis

X Chen, L An, X Fan, F Ju, B Zhang, H Sun, J Xiao… - PLoS …, 2017 - journals.plos.org
The dissacharide trehalose is an important intracellular osmoprotectant and the OtsA/B
pathway is the principal pathway for trehalose biosynthesis in a wide range of bacterial …

The repression of trehalose transport and metabolism in Escherichia coli by high osmolarity is mediated by trehalose-6-phosphate phosphatase

W Klein, U Ehmann, W Boos - Research in microbiology, 1991 - Elsevier
Trehalose transport and metabolism in Escherichia coli are induced by trehalose in the
growth medium but only at low osmolarity. In contrast, synthesis of internal trehalose as an …