Despite the importance of pain as a warning physiological system, chronic neuropathic pain
is frequently caused by damage in the nervous system, followed by persistence over a long …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

Abstract Treatment options for neuropathic pain have limited efficacy and use is fraught with
dose-limiting adverse effects. The endocannabinoid system has been elucidated over the …

The discovery of the endocannabinoid system nearly three decades ago generated great
interest among pain scientists. Moreover, its analogy with the opioid system in terms of …

Cannabis has been used for medicinal purposes for thousands of years. The prohibition of
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …

Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional …

A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Synthetic and naturally occurring cannabinoids are a focus of strong social, legal, and
medical controversy concerning their therapeutic utility, yet studies show that cannabinoids …

Cannabis extracts and synthetic cannabinoids are still widely considered illegal substances.
Preclinical and clinical studies have suggested that they may result useful to treat diverse …