An alteration in cell/matrix interactions is one of the suggested mechanisms leading to cyst
formation in polycystic kidney diseases. Most of these interactions are mediated by β1 …

Mutations in the PKD1 gene are responsible for autosomal dominant polycystic kidney
disease (ADPKD). Although PKD1 has been cloned and shown to be expressed at high …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

Polycystic kidney disease (PKD), in which epithelial cysts arise from or instead of normal
renal tubules, is one of the most common genetic diseases. It has both autosomal dominant …

Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a
common genetic disease in which cysts form from kidney tubules. The predicted product of …

Genetically based polycystic kidney diseases include autosomal dominant (ADPKD) and
recessive (ARPKD) polycystic kidney diseases, nephronophthisis and medullary cystic …

The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and
topology. To study the putative functions of polycystin-1, conditionally immortalized kidney …

This short review summarizes some information concerning what is known about matrix
adhesion molecules, focal adhesion proteins, and cell-cell adhesion molecules in normal …

Polycystin, the product of autosomal dominant polycystic kidney disease (ADPKD) 1 gene
(PKD1) is the cardinal member of a novel class of proteins. As a first step towards …

Studies of the nature and expression of the PKD-1 gene product, polycystin, have been
complicated by duplication of the PKD-1 gene, the low expression of the PKD-1 gene in …