Aims/hypothesis Type 2 diabetes is a chronic metabolic disorder associated with
devastating microvascular complications. Genome-wide association studies have identified …

The high-mobility group A1 (HMGA1) gene has been previously identified as a potential
novel candidate gene for susceptibility to insulin resistance and type 2 diabetes (T2D) …

Aims/hypothesis Variants of the high-mobility group A1 (HMGA1) gene have been shown to
be associated with insulin resistance and type 2 diabetes in individuals of European origin …

It has recently been suggested that the low-frequency c. 136–14_136–13insC variant in high-
mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes …

Context High-mobility group A1 (HMGA1) protein is a key regulator of insulin receptor
(INSR) gene expression. We previously identified a functional HMGA1 gene variant in 2 …

The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance is
associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease …

Background: High-mobility group AT-hook 1 (HMGA1) is an important regulator of the insulin
receptor gene. We have previously shown in three populations of white European ancestry …

Abstract Background Acute Myocardial infarction (AMI), a leading cause of morbidity and
mortality worldwide, is a dreadful acute complication of coronary atherosclerosis. Type 2 …

BOTH GENETIC AND ENVIRONMENTAL FACTORS CON-tribute to the pathogenesis of
type 2 diabetes mellitus (DM). Linkage analysis and genome-wide association studies have …

Type 2 diabetes mellitus (T2DM) is a complex disease in which both genetic and
environmental factors interact in determining impaired β-cell insulin secretion and peripheral …