Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β
F Xiaoye, L Hongming, W Lidong, D Xuming… - Frontiers in … - frontiersin.org
< p> Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
[HTML][HTML] Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
[HTML][HTML] Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction
Q Xiao, Y Zhao, L Ma, R Piao - Journal of Pharmacological Sciences, 2022 - Elsevier
Oxidative stress, as an important pathogenic factor, plays a critical role in acetaminophen
(APAP) overdose-induced acute liver failure (ALF). Thus, an antioxidative strategy may be a …
(APAP) overdose-induced acute liver failure (ALF). Thus, an antioxidative strategy may be a …
Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and …
L Yuan, X Ren, Y Wu, J Wang, H Xiao, X Liu - Biomedicine & Aging …, 2013 - Elsevier
Isoorientin (ISO) is a flavonoid compound, and possesses a significant antioxidant potential.
However, the effects of ISO on the oxidative damage in normal hepatocytes remain …
However, the effects of ISO on the oxidative damage in normal hepatocytes remain …
[HTML][HTML] Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway
H Lv, L Hong, Y Tian, C Yin, C Zhu, H Feng - Cell communication and …, 2019 - Springer
Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …
[HTML][HTML] Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway
L Zhao, J Zhang, C Hu, T Wang, J Lu, C Wu… - Frontiers in …, 2020 - frontiersin.org
Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …
[HTML][HTML] Apigenin attenuates acetaminophen-induced hepatotoxicity by activating AMP-activated protein kinase/carnitine palmitoyltransferase I pathway
J Zhang, X Liang, J Li, H Yin, F Liu, C Hu… - Frontiers in …, 2020 - frontiersin.org
Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the
clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of …
clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of …
Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury
W Xie, M Wang, C Chen, X Zhang, MF Melzig - Life sciences, 2016 - Elsevier
Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin
exhibited potential hepatoprotective effect in our previous study. The present investigation …
exhibited potential hepatoprotective effect in our previous study. The present investigation …
[PDF][PDF] Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against …
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …
Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo
X Li, S He, C Gao, H Deng, Y Liu, C Li… - Food and agricultural …, 2019 - Taylor & Francis
ABSTRACT Benzo [a] pyrene (BaP), a carcinogen, leads to the severe liver injury.
Isoorientin (ISO), a natural flavonoid, is known for its bioactivities, including anti-oxidation …
Isoorientin (ISO), a natural flavonoid, is known for its bioactivities, including anti-oxidation …