Threat-induced modulation of hippocampal and striatal memory systems during navigation of a virtual environment

J Goodman, M McClay, JE Dunsmoor - Neurobiology of learning and …, 2020 - Elsevier
The brain is composed of multiple memory systems that mediate distinct types of navigation.
The hippocampus is important for encoding and retrieving allocentric spatial cognitive maps …

Negative emotional experiences during navigation enhance parahippocampal activity during recall of place information

E Chan, O Baumann, MA Bellgrove… - Journal of cognitive …, 2014 - direct.mit.edu
It is known that the parahippocampal cortex is involved in object–place associations in
spatial learning, but it remains unknown whether activity within this region is modulated by …

Acute stress switches spatial navigation strategy from egocentric to allocentric in a virtual Morris water maze

DJH Van Gerven, T Ferguson, RW Skelton - Neurobiology of Learning and …, 2016 - Elsevier
Stress and stress hormones are known to influence the function of the hippocampus, a brain
structure critical for cognitive-map-based, allocentric spatial navigation. The caudate …

The relationships between trait anxiety, place recognition memory, and learning strategy

WR Hawley, EM Grissom, GP Dohanich - Behavioural brain research, 2011 - Elsevier
Rodents learn to navigate mazes using various strategies that are governed by specific
regions of the brain. The type of strategy used when learning to navigate a spatial …

[PDF][PDF] Stress disrupts human hippocampal-prefrontal function during prospective spatial navigation and hinders flexible behavior

TI Brown, SA Gagnon, AD Wagner - Current Biology, 2020 - cell.com
The ability to anticipate and flexibly plan for the future is critical for achieving goal-directed
outcomes. Extant data suggest that neural and cognitive stress mechanisms may disrupt …

The impact of threat of shock-induced anxiety on the neural substrates of memory encoding and retrieval

M Garibbo, J Aylward… - Social cognitive and …, 2019 - academic.oup.com
Dysfunctional memory processes are widely reported in anxiety disorders, but the
underlying neurocognitive mechanisms are unclear. Recent work shows that the impact of …

Location-dependent threat and associated neural abnormalities in clinical anxiety

B Suarez-Jimenez, NL Balderston, JA Bisby… - Communications …, 2021 - nature.com
Anxiety disorders are characterized by maladaptive defensive responses to distal or
uncertain threats. Elucidating neural mechanisms of anxiety is essential to understand the …

Gray matter differences correlate with spontaneous strategies in a human virtual navigation task

VD Bohbot, J Lerch, B Thorndycraft, G Iaria… - Journal of …, 2007 - Soc Neuroscience
Young healthy participants spontaneously use different strategies in a virtual radial maze, an
adaptation of a task typically used with rodents. Functional magnetic resonance imaging …

Disentangling hippocampal and amygdala contribution to human anxiety-like behavior

DR Bach, M Hoffmann, C Finke… - Journal of …, 2019 - Soc Neuroscience
Anxiety comprises a suite of behaviors to deal with potential threat and is often modeled in
approach–avoidance conflict tasks. Collectively, these tests constitute a predominant …

Reactivation of an aversive memory modulates learning strategy preference in male rats

WR Hawley, EM Grissom, JM Patel, KS Hodges… - Stress, 2013 - Taylor & Francis
Reminders of an aversive event adversely impact retrieval of hippocampus-dependent
memories and exacerbate stress-induced levels of anxiety. Interestingly, stress and anxiety …