Background Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) has
been linked to focal reductions in cerebral blood flow (CBF) and microvascular impairments …

Delayed cerebral ischemia (DCI) continues to be a sequela of aneurysmal subarachnoid
hemorrhage (aSAH) that carries significant morbidity and mortality. Aside from nimodipine …

Objectives: Impaired oxygen delivery due to reduced cerebral blood flow is the hallmark of
delayed cerebral ischemia following subarachnoid hemorrhage. Since anemia reduces …

Objectives Cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) may be one of the main
drivers of secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH) …

Abstract Background and Purpose In patients with subarachnoid hemorrhage (SAH), higher
hemoglobin (HGB) has been associated with better outcomes, but packed red blood cell …

Background and Purpose—The goal of this study was to examine the effects of hypertonic
saline on cerebral blood flow (CBF) in poor-grade patients with subarachnoid hemorrhage …

Background and Purpose—S-nitrosylated hemoglobin (S-nitrosohemoglobin) has been
implicated in the delivery of O2 to tissues through the regulation of microvascular blood flow …

Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in
patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for …

Background Anemia adversely affects cerebral oxygenation and metabolism after
subarachnoid hemorrhage (SAH) and is also associated with poor outcome. There is limited …

Exchange transfusion of large volumes of hemoglobin (Hb)-based oxygen carriers can
protect the brain from middle cerebral artery occlusion (MCAO). Hb in the carboxy state …