Highlights•Biological network models enable a mechanistic understanding of high-
throughput data.•Network response can be quantified for the impact of a given stimulus.•The …

Exposure to biologically active substances such as therapeutic drugs or environmental
toxicants can impact biological systems at various levels, affecting individual molecules …

Background High-throughput measurement technologies such as microarrays provide
complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …

Abstract Systems biology as a research field has emerged within the last few decades.
Systems biology, often defined as the antithesis of the reductionist approach, integrates …

Toxicogenomics is the study of the molecular effects of chemical, biological and physical
agents in biological systems, with the aim of elucidating toxicological mechanisms, building …

With the need to investigate alternative approaches and emerging technologies in order to
increase drug efficacy and reduce adverse drug effects, network biology offers a novel way …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

Current target-based drug discovery platforms are not able to predict drug efficacy and the
full spectrum of drug effects in organisms. Hence, many experimental drugs do not survive …

The new paradigm envisioned for toxicity testing in the 21st century advocates shifting from
the current animal-based testing process to a combination of in vitro cell-based studies, high …