Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …

This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

The generation of gametes falls between two reprogramming phases. These phases are
characterised by profound periods of transcriptional activity, which define and reinforce …

In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …