Sleep quality in efavirenz-treated Chinese HIV patients-comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms.
LSS Lee ShuiShan, TKW To KinWang… - 2014 - cabidigitallibrary.org
Seventy-two adult Chinese HIV-positive treatment-naïve patients were recruited in a study to
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and …
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and …
Sleep quality in efavirenz-treated Chinese HIV patients–comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms
Seventy-two adult Chinese HIV-positive treatment-naïve patients were recruited in a study to
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and …
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and …
Temporal changes of sleep disturbances and their associations with CYP450 2B6 polymorphism and plasma drug level in HIV patients on efavirenz
Neurological and sleep disturbances were commonly reported among HIV patients on
efavirenz (EFV), the pharmacokinetic pattern varies with different CYP450 2B6 G516T …
efavirenz (EFV), the pharmacokinetic pattern varies with different CYP450 2B6 G516T …
[HTML][HTML] The effect of rifampicin-based antitubercular therapy and cytochrome P450 2B6 genotype on efavirenz mid-dosing interval concentrations in a South African …
Background Rifampicin may decrease efavirenz concentrations by inducing expression of
cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolises efavirenz. The CYP2B6 …
cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolises efavirenz. The CYP2B6 …
Correlation of CYP2B6-516G> T polymorphism with plasma efavirenz concentration and depression in HIV-infected adults in Northern Thailand
L Aurpibul, N Chotirosniramit… - Current HIV …, 2012 - ingentaconnect.com
Background: Single nucleotide polymorphism of the hepatic cytochrome P450 isoenzyme
2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We …
2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We …
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in …
Single-nucleotide polymorphisms (SNPs) in CYP2B6 have been shown to predict variation
in plasma efavirenz concentrations, but associations between these SNPs and efavirenz …
in plasma efavirenz concentrations, but associations between these SNPs and efavirenz …
Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes
DW Haas, A Kwara, DM Richardson… - Journal of …, 2014 - academic.oup.com
Objectives Efavirenz is widely prescribed for HIV-1 infection, and CYP2B6 polymorphisms
516G→ T and 983T→ C define efavirenz slow metabolizer genotypes. To identify genetic …
516G→ T and 983T→ C define efavirenz slow metabolizer genotypes. To identify genetic …
A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot …
P Damronglerd, C Sukasem… - Pharmacogenomics …, 2015 - Taylor & Francis
Objective We aimed at comparing clinical/immunological outcomes in human
immunodeficiency virus (HIV)-infected patients who were treated with CYP2B6-guided and …
immunodeficiency virus (HIV)-infected patients who were treated with CYP2B6-guided and …
Impact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients
U Sandkovsky, AT Podany, CV Fletcher… - Journal of …, 2016 - academic.oup.com
Background Pharmacokinetics (PK) and pharmacodynamics of efavirenz and its 8-hydroxy
metabolite (8-OH-efavirenz) have not been robustly evaluated in older HIV-infected persons …
metabolite (8-OH-efavirenz) have not been robustly evaluated in older HIV-infected persons …
High plasma efavirenz concentration and CYP2B6 polymorphisms in Thai HIV-1 infections
C Sukasem, M Chamnanphon, N Koomdee… - Drug metabolism and …, 2013 - Elsevier
Efavirenz is mainly metabolized by cytochrome P450 2B6 (CYP2B6). This study aimed to
examine the frequencies of CYP2B6 and the association between CYP2B6 polymorphisms …
examine the frequencies of CYP2B6 and the association between CYP2B6 polymorphisms …