Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension

A Georgescu, D Popov, E Dragan, E Dragomir… - European journal of …, 2007 - Elsevier
This study aims to decipher the potential effects of nebivolol in prevention and/or regression
of renal artery dysfunction in diabetes associated with hypertension. Renal arteries were …

Long-term treatment with nebivolol attenuates renal damage in Zucker diabetic fatty rats

JE Toblli, G Cao, JF Giani, MC Munoz… - Journal of …, 2011 - journals.lww.com
Objective Atenolol, a first-generation β-blocker, effectively reduces blood pressure, although
its use in metabolic syndrome remains controversial. Accordingly, this study evaluated the …

Nebivolol ameliorated kidney damage in Zucker diabetic fatty rats by regulation of oxidative stress/NO pathway: Comparison with captopril

Y Wang, W An, F Zhang, M Niu, Y Liu… - Clinical and …, 2018 - Wiley Online Library
The aim was to evaluate the effects and mechanisms of nebivolol on renal damage in
Zucker diabetic fatty (ZDF) rats, in comparison with those of atenolol and captopril. Animals …

Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats

JE Toblli, G Cao, C Rivas, M Munoz, J Giani… - Journal of …, 2010 - journals.lww.com
Background Although effective in reducing blood pressure, therapy with a first-generation β-
blocker is currently controversial in metabolic syndrome due to its negative impact on …

Case study: the link between hypertension and diabetes

GL Bakris, ER Gonzalez - Journal of Managed Care Pharmacy, 2007 - jmcp.org
BACKGROUND: Many diabetics develop hypertension, and it is a major risk factor for
cardiovascular and microvascular complications. OBJECTIVE: To review a case study of a …

Nebivolol Ameliorates Nitric Oxide–Deficient Hypertension

LA Fortepiani, MC Ortíz, NM Atucha… - The Scientific World …, 2002 - hindawi.com
Nebivolol is a new selective beta 1-adrenoceptor antagonist with nitric oxide (NO)–releasing
properties. In the present study we have analyzed whether nebivolol affects the …

Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of β-blockers

R Preston Mason, R Kubant, RF Jacob… - American journal of …, 2009 - academic.oup.com
Background Endothelial cell (EC) dysfunction contributes to hypertension and mechanisms
of atherosclerosis. Agents that improve EC function may provide vascular protection …

Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin

EH Akamine, EM Kawamoto, C Scavone… - Journal of vascular …, 2006 - karger.com
Diabetes-induced vascular dysfunction has mainly been studied in males. However, the
mechanisms involved may not correspond to those in females. Here we analyzed the effects …

Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus: the YESTONO study

AC Schmidt, C Graf, K Brixius, J Scholze - Clinical drug investigation, 2007 - Springer
Background: Effective blood pressure (BP)-lowering therapy is regarded as the most
important intervention in diabetes mellitus. Nebivolol is commonly used for the treatment of …

Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study

N Tzemos, PO Lim, TM MacDonald - Circulation, 2001 - Am Heart Assoc
Background Vascular endothelial dysfunction may predict future atherosclerosis. Hence, an
antihypertensive agent that reverses endothelial dysfunction and lowers blood pressure …