Severe iodine deficiency is characterized by goiter, preferential synthesis, and secretion of
T3 in thyroids, hypothyroxinemia in plasma and tissues, normal or low plasma T3, and …

In the present study we show the expression profiles of both type 1 and type 2 iodothyronine
deiodinases (D1 and D2) in a wide spectrum of mouse tIssues, and D2 regulation by thyroid …

The three iodothyronine deiodinases (D1, D2, and D3) play major roles in determining the
tissue and cellular content of the active thyroid hormone, T3. The D1 and D2 5′-deiodinate …

Abstract The C3H/HeJ mouse presents an inherited type 1 deiodinase (D1) deficiency that
results in elevated serum thyroxine (T4), whereas TSH and tri-iodothyronine (T3) …

To provide new insights into the in vivo regulation of iodothyronine deiodinases in the
different tissues of the rat, we have evaluated the effects on these enzymatic activities of T4 …

The hypothesis tested was whether marginal iodine deficiency for a period of 6 wk affects
iodothyronine deiodinase activities in liver and brain of rats. Male rats were fed purified diets …

Abstract The type 1 deiodinase (D1) catalyzes the monodeiodination of T4 to produce T3,
the active thyroid hormone. In the C3H mouse, hepatic D1 and the dio1 messenger RNA …

The type 3 deiodinase (D3) is a selenoenzyme that inactivates thyroid hormones and is
highly expressed during development and in the adult central nervous system. We have …

The goal of the present investigation was to analyze the types 2 (D2) and 3 (D3)
iodothyronine deiodinases in various structures within the central nervous system (CNS) in …

We measured thyroxine 5'-deiodinase I (T (4) 5'DI) activity in thyroid, liver, and kidney and
thyroxine 5'-deiodinase II (T (4) 5'D-II) activity in brown adipose tissue (BAT) in rats on a low …