Oxidative stress is a natural phenomenon in the body. Under physiological conditions
intracellular reactive oxygen species (ROS) are normal components of signal transduction …

Although ammonia is considered the main factor involved in the pathogenesis of hepatic
encephalopathy (HE), it correlates well with the severity of HE in acute liver failure, but not in …

Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of
hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and …

The pathogenesis of hepatic encephalopathy (HE) remains elusive. While it is clear that
ammonia is the likely toxin and that astrocytes are the main target of its neurotoxicity …

Background: Oxidative stress induced by a high ammonia concentration has been
suggested to be implicated in the pathophysiology of hepatic encephalopathy (HE) …

Cirrhotic patients may suffer minimal hepatic encephalopathy (MHE), with mild cognitive
impairment. 3-Nitro-tyrosine levels are a good biomarker for diagnosis of the cognitive …

Abstract Objectives of the International Society for Hepatic Encephalopathy and Nitrogen
Metabolism Commission were to identify well‐characterized animal models of hepatic …

Abstract Background & Aims The pathogenesis of hepatic encephalopathy (HE) is
multifactorial and often associated with the development of brain oedema. In addition to …

Acute hyperammonemia (HA) induced oxidative stress in the brain is considered to play
critical roles in the neuropathology of end stage hepatic encephalopathy (HE). Moderate …

Hepatic encephalopathy (HE) defines a primary gliopathy associated with acute and chronic
liver disease. Astrocyte swelling triggered by ammonia in synergism with different …