Background Observational studies and some randomized controlled trials have suggested
that nutritional supplementation could be a possible intervention pathway to prevent …

Background It is unknown whether multidomain interventions, which might preserve late-life
cognition, affect Alzheimer's disease pathology. Previous studies measured cerebrospinal …

Abstract Background & Aims It has been revealed good nutritional status and no physical
frailty, which are modifiable lifestyle factors, are linked to less cognitive decline and a lower …

Objective There is increasing evidence to suggest that diet, one of the most important
modifiable environmental factors, may play a role in preventing or delaying cognitive decline …

Omega-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) have been associated with slower rates of cognitive decline …

Abstract Alzheimer's disease (AD), the most common form of dementia, is preceded by years
of silent pathological change. Our objective was to examine the associations between …

Objective: Aggregation of phosphorylated tau (pTau) is a hallmark feature of Alzheimer's
disease (AD). Novel assays now allow pTau to be measured in plasma. Elevated plasma …

Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early
changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels …

OBJECTIVE The Multidomain Alzheimer Preventive Trial (MAPT study) was designed to
assess the efficacy of isolated supplementation with omega-3 fatty acid, an isolated …

Objective: The widely reported associations between various nutrients and cognition may
occur through many biologic pathways including those of β-amyloid (Aβ). However, little is …