Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of
lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

SJ Cherra III, RK Dagda and CT Chu (2010) Neuropathology and Applied Neurobiology36,
125–132 Autophagy and neurodegeneration: survival at a cost? Protein aggregation …

The most prevalent pathological features of many neurodegenerative diseases are the
aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy …

Autophagy is an evolutionally conserved process by which cytoplasmic contents including
protein aggregates and damaged organelles such as mitochondria and lysosomes, are …

J. Neurochem.(2011) 118, 315–316. Abstract Autophagy is an evolutionarily conserved
homeostatic process for the turnover of cellular contents, organelles and misfolded proteins …

Autophagy is a catabolic pathway by which misfolded proteins or damaged organelles are
engulfed by autophagosomes and then transported to lysosomes for degradation. Recently …

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling
of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of …

Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis,
has recently been the focus of numerous human diseases and conditions, such as aging …

Autophagy is a highly conserved intracellular pathway involved in the elimination of proteins
and organelles by lysosomes. Known originally as an adaptive response to nutrient …