The endogenous fatty acid ethanolamide, palmitylethanolamide, alleviated, in a dose-
dependent manner, pain behaviors elicited in mice by injections of formalin (5 …

Background and Purpose: Cannabinoids are associated with analgesia in acute and chronic
pain states. A spectrum of central cannabinoid (CB1) receptor‐mediated motor and …

This study assessed the effects of two N-acylethanolamides in established rat models of
visceral and somatic inflammatory pain.(1) The therapeutic effects of the cannabinoid …

Cannabinoid-based medicines have therapeutic potential for the treatment of pain.
Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase …

The brain produces at least five compounds that possess sub-micromolar affinity for
cannabinoid receptors: anandamide, 2-arachidonoylglycerol, noladin ether, virodhamine …

Background and purpose: We have previously demonstrated antinociceptive effects of fatty
acid amide hydrolase (FAAH) inhibition that were accompanied by increases in the levels of …

It has been suggested that administration of a cannabinoid CB1 (SR141716A [N-(piperidin-1-
yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1-H-pyrazole-3-carboxamide]) and …

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in
endogenous protective mechanisms activated as a result of stimulation of inflammatory …

Although the N-arachidonoyl ethanolamine (anandamide) binds to cannabinoid receptors
and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid …

Antinociceptive effects of cannabinoids are well documented. However, the physiological
role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the …