The advent of functional genomics has enabled the molecular biosciences to come a long
way towards characterizing the molecular constituents of life. Yet, the challenge for biology …

Systems biology is a new field in biology that aims at system-level understanding of
biological systems. While molecular biology has led to remarkable progress in our …

Systems biology is a comprehensive quantitative analysis of the manner in which all the
components of a biological system interact functionally over time. Such an analysis is …

Abstract Systems analysis has historically been performed in many areas of biology,
including ecology, developmental biology and immunology. More recently, the genomics …

With the ever-increasing flow of high-throughput gene expression, protein interaction and
genome sequence data, researchers gradually approach a system-level understanding of …

The importance of regulatory control in metabolic processes is widely acknowledged, and
several enquiries (both local and global) are being made in understanding regulation at …

The idea that multi-scale dynamic complex systems formed by interacting macromolecules
and metabolites, cells, organs and organisms underlie some of the most fundamental …

Abstract Systems-biology approaches, which are driven by genome sequencing and high-
throughput functional genomics data, are revolutionizing single-cell-organism biology. With …

Associations between the dynamic community of microbes (the microbiota) and the host they
colonize appear to be vital for ensuring host health. Microbe-host communication is actively …

The immeasurable complexity at every level of biological organization creates a daunting
task for understanding biological function. Here, we highlight the risks of stripping it away at …