Genetic, clinical, and sociodemographic factors associated with stimulant treatment outcomes in ADHD

I Brikell, T Wimberley, C Albiñana… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: Stimulant medications are effective for treating attention deficit hyperactivity
disorder (ADHD), yet discontinuation and switch to nonstimulant ADHD medications are …

Neurobiology and genetics of ADHD in adults

TJ Spencer - CNS spectrums, 2008 - cambridge.org
Treatment of attention-deficit/hyperactivity disorder (ADHD) may positively impact the
neurobiology of adult patients with ADHD. Treatment may also minimize impairment from …

The pharmacogenomic era: promise for personalizing attention deficit hyperactivity disorder therapy

MA Stein, JJ McGough - Child and adolescent psychiatric clinics of North …, 2008 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) treatment is often determined empirically
through trial and error until an adequate response is obtained or side effects occur. ADHD is …

Attention-deficit/hyperactivity disorder pharmacogenomics

JJ McGough - Biological psychiatry, 2005 - Elsevier
Although the efficacy of medications for attention-deficit/hyperactivity disorder (ADHD) is well
demonstrated in clinical trials, substantial numbers of patients fail to remain on therapy, and …

ADHD pharmacogenetics across the life cycle: new findings and perspectives

EM Bruxel, GC Akutagava‐Martins… - American Journal of …, 2014 - Wiley Online Library
Attention‐deficit/hyperactivity disorder (ADHD) is a complex and heterogeneous disorder,
affecting individuals across the life cycle. Although its etiology is not yet completely …

Genetic liability to ADHD and substance use disorders in individuals with ADHD

T Wimberley, E Agerbo, HT Horsdal, C Ottosen… - …, 2020 - Wiley Online Library
Aims 1) To investigate whether genetic liability to attention‐deficit/hyperactivity disorder
(ADHD), indexed by polygenic risk scores for ADHD (PRS‐ADHD), is associated with …

Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene‐based tests, genome‐wide variation, and SNP heritability

LC Bidwell, JC Gray, J Weafer… - American Journal of …, 2017 - Wiley Online Library
Although the heritability of ADHD is estimated to be high, identifying specific genetic markers
remains challenging. Most studies to date have examined the genetic basis of ADHD by …

Progress and promise of attention-deficit hyperactivity disorder pharmacogenetics

TE Froehlich, JJ McGough, MA Stein - CNS drugs, 2010 - Springer
One strategy for understanding variability in attention-deficit hyperactivity disorder (ADHD)
medication response, and therefore redressing the current trial-and-error approach to ADHD …

The genetics of ADHD: a literature review of 2005

SA Khan, SV Faraone - Current Psychiatry Reports, 2006 - Springer
Investigations into the genetic basis of attention-deficit/hyperactivity disorder (ADHD)
continue to yield compelling results as candidate gene studies reveal more information …

[HTML][HTML] Facing the methodological challenge in dissecting the genetics of ADHD: a case for deep phenotyping and heterogeneity reduction

SM Sengupta, N Grizenko, MÈ Fortier… - Journal of the …, 2020 - ncbi.nlm.nih.gov
Objective The aetiology of ADHD is complex, with genetic and environmental factors both
implicated in the disorder. The most recent ADHD genome-wide association study identified …