▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …

Sixty years ago the clinical neurophysiology of epilepsy had progressed to the stage that it
posed questions that could be addressed by major advances in cellular electrophysiology …

Generalized epilepsy involves abnormally synchronized activity in large‐scale neuronal
networks. Burst firing of action potentials is a potent mechanism for increasing neural …

A seizure (from the Latin sacire—to take possession of) is the clinical manifestation of an
abnormal, excessive, hypersynchronous discharge of a population of cortical neurons …

Purpose: The “silent period” is a characteristic of human localization‐related symptomatic
epilepsy. In mesial temporal lobe epilepsy (MTLE), it follows an initial precipitating injury …

Convulsive seizures in animal models usually involve one or more of the following
components:(1) limbic motor seizures,(2) explosive running-bouncing clonic seizures, and …

The brain is naturally considered as a network of interacting elements which, when
functioning properly, produces an enormous range of dynamic, adaptable behavior …

Seizures occur in groups of neurons and involve complex interactions across several
regions. The focus of much epilepsy research has been on changes in single neuronal …

Partial complex seizures are known to arise from abnormal firing of neurons in cortex that
has histologic abnormalities associated with tumors, infarcts, or neuron loss. The latter …

The cellular phenomena underlying focal epilepsy are currently understood in the context of
contemporary concepts of cellular and synaptic function. Interictal discharges appear to be …