Proliferation of dendritic cell (DC)—restricted progenitor cells in bone marrow compartment
is tightly regulated at steady state and responds to multiple tissue-specific triggers during …

DCs are necessary and sufficient for induction of allergic airway inflammation. CD11b+ DCs
direct the underlying Th2 immunity, but debate surrounds the function of CD103+ DCs in …

Maladaptive, Th2-polarized inflammatory responses are integral to the pathogenesis of
allergic asthma. As regulators of T cell activation, dendritic cells (DCs) are important …

Although dendritic cells (DCs) play an important role in sensitization to inhaled allergens,
their function in ongoing T helper (Th) 2 cell–mediated eosinophilic airway inflammation …

Sensitization to inhaled allergens is dependent on activation of conventional dendritic cells
(cDCs) and on the adaptor molecule, MyD88. However, many cell types in the lung express …

Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host …

Neutrophil mobilization, recruitment, and clearance must be tightly regulated as
overexuberant neutrophilic inflammation is implicated in the pathology of chronic diseases …

Pulmonary dendritic cells (DC) can induce both tolerogenic as well as inflammatory immune
responses in the lung. Conversely, little is known about the impact of ongoing airway …

Protease-activated receptor 2 (PAR-2), an airway epithelial pattern recognition receptor
(PRR), participates in the genesis of house dust mite–induced (HDM-induced) asthma …

Emerging evidence suggests a mechanistic role for myeloid-derived suppressor cells
(MDSCs) in lung diseases like asthma. Previously, we showed that adoptive transfer of …