Allopurinol is the drug most widely used to lower the blood concentrations of urate and,
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …

Allopurinol is a widely used drug in the management of hyperuricaemia. It is rapidly and
extensively absorbed following oral administration. The major and active metabolite …

An high-pressure liquid chromatographic method was used to measure allopurinol and
oxipurinol in plasma and urine in 6 healthy volunteers after a single intravenous or oral dose …

Aims The prevalence of hyperuricaemia and gout increases with age as does the incidence
of adverse effects to allopurinol, the major uric acid lowering drug. The present study was …

1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma
concentrations of oxipurinol and uric acid and the urinary production of uric acid were …

A spectrophotometric assay for measuring allopurinol and oxipurinol has been developed
which can detect as little as 5× 10− 8 M of each in serum and urine. With this assay, serum …

1 Eight healthy subjects received 50, 100, 300, 600 and 900 mg allopurinol daily for 1 week
each, in random order with 1 week separating each treatment period. The pre‐dose plasma …

A life-threatening toxicity syndrome consisting of an erythematous, desquamative skin rash,
fever, hepatitis, eosinophilia, and worsening renal function in 78 patients receiving …

Objective. To investigate the pharmacokinetic and pharmacodynamic interaction between
probenecid and oxypurinol (the active metabolite of allopurinol) in patients with gout …

Background: Gout is a common and challenging problem in South Auckland, New Zealand.
Allopurinol is widely used but urate reduction remains unsatisfactory. Allopurinol dosing …