Peroxisome proliferator-activated receptors (PPARs) are expressed on vascular tissue. To
investigate the direct vasoprotective effects of PPARγ and PPARα ligands, pioglitazone (3 …

The aim of the present study was to investigate the causal relationship between peroxisome
proliferator‐activated receptor (PPAR) and endothelium‐dependent relaxation in …

Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease.
Herein, we have analyzed if the peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) …

Background—Peroxisome proliferator–activated receptor (PPAR) signaling pathways have
been reported to exert anti-inflammatory effects and attenuate atherosclerosis formation …

Atherosclerosis is an inflammatory disease involving the immune response. In addition to
lowering the cholesterol level, the peroxisome proliferator-activated receptor α (PPAR-α) can …

Objective—There has been accumulating evidence demonstrating that activators for
peroxisome proliferator-activated receptor α (PPARα) have antiinflammatory …

Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated
transcription factors that include PPAR-α, PPAR-γ, and PPAR-δ. We hypothesized that …

Objective—Endothelial activation is implicated in atherogenesis and diabetes. The role of
peroxisome proliferator-activated receptor-δ (PPAR-δ) in endothelial activation remains …

Oxidative stress plays an important role in diabetic vascular dysfunction. The sources and
regulation of reactive oxygen species production in diabetic vasculature continue to be …

Objective: To study the effect of pioglitazone (a PPAR gamma agonist) treatment on blood
pressure, endothelial function, and oxidative stress in streptozotocin (STZ)-induced diabetic …