OBJECTIVES: Sex steroid hormones play roles in the regulation of pituitary hormone
synthesis and secretion. Here we investigated the role of estradiol (E2) and progesterone …

Our previous work demonstrated that in vivo estradiol (E2) administration to ovariectomized
rats suppressed the transcription of the LH subunit genes within 4 h. To determine whether …

LH and FSH play critical roles in mammalian reproduction by mediating steroidogenesis and
gametogenesis in the gonad. Gonadal steroid hormone feedback to the hypothalamus and …

Progesterone is able to bring about an LH and FSH surge in the estrogen-primed
ovariectomized rat while dexamethasone brings about selective FSH release. The purpose …

We investigated whether Jun N-terminal kinase (JNK) and p38 mediate gonadotropin
subunit transcriptional responses to pulsatile GnRH in normal rat pituitaries. A single pulse …

We have recently demonstrated that the rat ovary expresses LHβ, FSHβ, and the common
alpha subunit mRNA. In the present report, we studied the regulation of LHβ and of …

Recently, several cis-regulatory elements that play roles in LHβ gene expression, and their
cognate DNA-binding transcription factors, have been identified. These factors include Sp1 …

The αT3-1 cells are immortalized anterior pituitary gonadotropes which express
gonadotropin-α subunit gene. These cells contain receptors for gonadotropin releasing …

The pulsatile release of GnRH by the hypothalamus is required to stimulate the pituitary-
gonadal axis, and variations in GnRH pulse frequency are associated with differential …

Tight regulation of luteinizing hormone-β subunit (LHβ) expression is critical for
differentiation and maturation of mammalian sexual organs and reproductive function. Two …