The phosphatidylinositol 3-kinase (PI3K)/Akt pathway elicits a survival signal against
multiple apoptotic insults. In addition, phase II enzymes such as heme oxygenase-1 (HO-1) …

Resveratrol (3, 4′, 5-trihydroxy stilbene), a phytoalexin found in the skin and seeds of
grapes, has been reported to possess anti-inflammatory, anticarcinogenic, and antioxidant …

The transcription factor Nrf2, which normally exists in an inactive state as a consequence of
binding to a cytoskeleton-associated protein Keap1, can be activated by redox-dependent …

The aim of the present study was to examine the cytoprotective effect of eckol, a
phlorotannin found in Ecklonia cava and to elucidate underlying mechanisms. Heme …

Antioxidant response element (ARE) regulates the induction of a number of cellular
antioxidant and detoxifying enzymes. However, the signaling pathways that lead to ARE …

The transcription factor Nrf2 (nuclear factor E2-related factor 2) regulates the expression of
antioxidant phase II genes and contributes to preserve redox homeostasis and cell viability …

Epigallocatechin 3-gallate (EGC19194), the major polyphenol found in green tea, exerts
antiproliferative and proapoptotic effects in many cancer cells. However, we found that …

Oxidative stress has been considered as a major cause of cellular injuries in a variety of
clinical abnormalities, especially neural diseases. Our aim of research is to investigate the …

Plant growth under abiotic stress conditions significantly enhances intracellular generation
of reactive oxygen species (ROS). Oxidative status of plant cells is directly affected by the …

Heme oxygenase-1 (HO-1) is a cytoprotective enzyme activated by various phytochemicals
and we examined the ability of Epigallocatechin-3-gallate (EGCG), the major constituent of …