Context: Sulfasalazine (SAS) is a drug prescribed for pregnant and breastfeeding women
with chronic inflammatory bowel diseases. SAS treatment induces transitory infertility in both …

Aims Sulfasalazine (SAS) is the first line drug in the treatment of chronic inflammatory bowel
diseases in pregnant women. SAS and its metabolites cross the placenta and can be …

There are reports of sulfasalazine (Salazosulfapyridine; SASP)-induced reproductive
toxicity, but there it is not known whether the SASP molecule or its intestinal metabolites are …

The mechanism of action of sulfasalazine (SASP) in male infertility is not well elucidated. For
it, an oxidative stress-like mechanism inductor of infertility was hypothesized. Adult male …

Sulfasalazine (2-hydroxy-5-[[4-[(2-pyridinylamino) sulfonyl] phenyl] azo] benzoic acid; SASP)
was administered to rats in a short-term male reproductive toxicity study to further examine …

Sulfasalazine (SASP) has been reported to depress the fertility in men and experimental
male animals, but the fundamental mechanisms of infertility caused by SASP are still …

Clinical and experimental evidence indicates that exposure to relatively large doses of
acetylsalicylic acid (ASA) prolongs parturition. However, little is known about the dose …

Citation Nath CA, Ananth CV, Smulian JC, Peltier MR. Can sulfasalazine prevent infection‐
mediated pre‐term birth in a murine model? Am J Reprod Immunol 2010; 63: 144–149 …

Objective To determine the (reversible) antifertility effect in the male rat of sulfasalazine, a
common therapy for inflammatory bowel disease. Methods Sulfasalazine (120, 250 and 500 …

Background The antifertility effect of ampicillin (AMP, 40 mg/kg) and sulphasalazine or
salicylazosulfapyridine (SASP, 300,450 and 600 mg/kg) in male rats has been reported …