Successful translation of findings derived from preclinical studies into effective therapies is
critical in biomedical research. Lack of robustness and reproducibility of the preclinical data …

Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α …

Death receptor-mediated apoptosis is a key mechanism for the control of immune responses
and dysregulation of this pathway may lead to autoimmunity. Cellular FLICE-inhibitory …

Death receptors belong to the tumor necrosis factor receptor superfamily and can induce
apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) …

It is reported that the agonistic antibodies against death receptors 4 and 5 (DR4, DR5) are
cytotoxic to various cancer cells. In the present study, the sensitivity of five human lung …

Deregulation of apoptosis is common in cancer and is often caused by overexpression of
anti-apoptotic proteins in tumour cells. One important regulator of apoptosis is the cellular …

Dysregulation of c-FLIP (cellular FADD-like IL-1β-converting enzyme inhibitory protein) has
been shown in several diseases including cancer, Alzheimer's disease, and chronic …

Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
major antiapoptotic protein and an important cytokine and chemotherapy resistance factor …

Cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (c-FLIP) is a major
resistance factor and critical anti-apoptotic regulator that inhibits tumor necrosis factor-alpha …

The catalytically inactive caspase-8-homologous protein, c-FLIP, is a potent antiapoptotic
protein highly expressed in various types of cancers. c-FLIP competes with caspase-8 for …