Tissue kallikrein has protective function against various types of injury. In this study, we
investigated whether exogenous pancreatic kininogenase (PK) conferred renoprotection in …

Background Tissue kallikrein offers a wide spectrum of biological activity in the protection
against various types of injury. However, information on its role in tacrolimus (TAC)-induced …

Background/Aims: We aimed to evaluate whether pancreatic kininogenase (PKase) can
relieve renal fibrosis and investigate its mechanisms in diabetic nephropathy (DN) rats …

Levels of tissue kallikrein (TK) are significantly lower in the urine of patients with kidney
failure, and TK expression is specifically diminished in rat kidney after recovery from …

Renal fibrosis is a common pathological change in all stages of kidney disease.
Kangxianling decoction was widely used in patients with chronic kidney disease, which …

The progression of renal disease displays several characteristics, including proteinuria,
apoptosis, inflammation, and fibrosis. In this study, we investigated the effect of long-term …

The underlying pathogenesis of chronic kidney disease involves an activated renin-
angiotensin system and systemic inflammation which ultimately develop renal injury …

The kallikrein-kinin system has been shown to be involved in the development of diabetic
nephropathy, but specific mechanisms are not fully understood. Here, we determined the …

The injury of endothelial cells is one of the initiating factors in restenosis after endovascular
treatment. Human urinary kallidinogenase (HUK) is a tissue kallikrein which is used for …

Despite many readily available therapies, hypertensive kidney disease remains the second
most prevalent cause of end-stage renal disease after diabetes, and continues to burden …