Potential nexus of non-alcoholic fatty liver disease and type 2 diabetes mellitus: insulin resistance between hepatic and peripheral tissues

W Mu, X Cheng, Y Liu, Q Lv, G Liu, J Zhang… - Frontiers in …, 2019 - frontiersin.org
The liver is the central metabolic organ and plays a pivotal role in regulating homeostasis of
glucose and lipid metabolism. Aberrant liver metabolism promotes insulin resistance, which …

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

AL Birkenfeld, GI Shulman - Hepatology, 2014 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are
all strongly associated and are all reaching epidemic proportions. Whether there is a causal …

Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver

T Takamura, H Misu, T Ota, S Kaneko - Endocrine journal, 2012 - jstage.jst.go.jp
Obesity is less common in the Asian population, but Asian people may be susceptible to
obesity-associated metabolic dysregulation. Accumulating evidence suggests that insulin …

Nonalcoholic fatty liver disease and type 2 diabetes: common pathophysiologic mechanisms

C Saponaro, M Gaggini, A Gastaldelli - Current diabetes reports, 2015 - Springer
Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for advanced liver
disease, type 2 diabetes (T2DM), and cardiovascular diseases. The prevalence of NAFLD in …

Insulin resistance across the spectrum of nonalcoholic fatty liver disease

A Armandi, C Rosso, GP Caviglia, E Bugianesi - Metabolites, 2021 - mdpi.com
Insulin resistance (IR) is defined as a lower-than-expected response to insulin action from
target tissues, leading to the development of type 2 diabetes through the impairment of both …

Risk of type 2 diabetes in patients with non-alcoholic fatty liver disease: causal association or epiphenomenon?

G Targher, G Marchesini, CD Byrne - Diabetes & metabolism, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver
diseases worldwide, causing considerable liver-related mortality and morbidity. Over the last …

Shedding light on non-alcoholic fatty liver disease: Pathogenesis, molecular mechanisms, models, and emerging therapeutics

R Khairnar, MA Islam, J Fleishman, S Kumar - Life Sciences, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder globally
impacting an estimated 25% of the population associated with severe consequences such …

Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside

K Gariani, J Philippe, FR Jornayvaz - Diabetes & metabolism, 2013 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in
the developed countries. There is also growing evidence from basic and clinical research …

[HTML][HTML] The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)

DM Tanase, EM Gosav, CF Costea… - Journal of diabetes …, 2020 - hindawi.com
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …

[PDF][PDF] Modulation of insulin resistance in nonalcoholic fatty liver disease

RS Khan, F Bril, K Cusi, PN Newsome - Hepatology, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general
population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to …