Prolactinoma is the most common type of primary pituitary tumors. It occurs more frequently
in women than in men. Dopaminergic agonists are effective in the shrinkage of prolactin …

Prolactin-secreting adenomas (prolactinomas) are the most prevalent form of pituitary
tumors in humans. Our knowledge of the formation of these tumors is limited. Experimental …

Abstract In female Long-Evans rats, development of prolactin cell adenomas is preceded by
hyperplasia of prolactin cells, suggesting that factors affecting the endocrine function of …

✓ The factors responsible for the production of prolactin-secreting tumors are obscure. One
hypothesis, that chronic loss of dopamine control from the hypothalamus may be associated …

Rats with estrogen-induced prolactin-producing pituitary adenoma (E2-PRLoma) have been
employed as an animal model of human PRL-producing pituitary adenoma in a large …

Since anterior pituitary expresses prolactin receptors, prolactin secreted by lactotropes could
exert autocrine or paracrine actions on anterior pituitary cells. In fact, it has been observed …

Earlier studies showed that melatonin reduced the growth of 17‐β‐estradiol (E2)‐induced
rat pituitary prolactin‐secreting tumor (prolactinoma) in vivo. The mechanisms of melatonin's …

Chronic estrogen treatment induces prolactin (PRL)-secreting pituitary tumors in laboratory
animals. To determine earlier events of tumorigenesis, we studied cell proliferation in the …

Prolactin (PRL)-secreting tumors are the most common pituitary tumor type seen in rats,
mice, and man (Ito et al., 1972; Post et al., 1980; Schechter et al., 1981; Meites, 1981) …

Simple Summary This review updates recent advances in the pathogenesis, diagnosis, and
therapy of prolactinoma. Prolactinomas, comprising 30–50% of all pituitary neuroendocrine …