Working toward the Future: Insights into Francisella tularensis Pathogenesis and Vaccine Development

RD Pechous, TR McCarthy… - … and molecular biology …, 2009 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Molecular and Genetic Basis of Pathogenesis in Francisella Tularensis

JR Barker, KE Klose - Annals of the New York Academy of …, 2007 - Wiley Online Library
The genetic means of pathogenesis of Francisella tularensis are poorly understood. F.
tularensis is able to survive and replicate within macrophages, and a virulence factor, MglA …

Mechanisms of Francisella tularensis intracellular pathogenesis

J Celli, TC Zahrt - Cold Spring Harbor …, 2013 - perspectivesinmedicine.cshlp.org
Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

The unraveling panoply of Francisella tularensis virulence attributes

KL Meibom, A Charbit - Current opinion in microbiology, 2010 - Elsevier
Francisella tularensis is a highly infectious Gram-negative bacterium causing the zoonotic
disease tularemia. This facultative intracellular pathogen multiplies in vivo mainly inside …

Francisella tularensis: unravelling the secrets of an intracellular pathogen

PCF Oyston - Journal of medical microbiology, 2008 - microbiologyresearch.org
Francisella tularensis has been recognized as the causative agent of tularaemia for almost a
century. Since its discovery in 1911, it has been shown to infect a wide range of hosts …

Virulence determinants and protective antigens of Francisella tularensis

A Sjöstedt - Current opinion in microbiology, 2003 - Elsevier
Very little is known about virulence mechanisms of the highly virulent bacterium Francisella
tularensis. Specific genetic features of F. tularensis have been obstacles for the …

A Francisella tularensis Pathogenicity Island Required for Intramacrophage Growth

FE Nano, N Zhang, SC Cowley, KE Klose… - Journal of …, 2004 - Am Soc Microbiol
Francisella tularensis is a gram-negative, facultative intracellular pathogen that causes the
highly infectious zoonotic disease tularemia. We have discovered a ca. 30-kb pathogenicity …

Attenuated Francisella novicida Transposon Mutants Protect Mice against Wild-Type Challenge

R Tempel, XH Lai, L Crosa, B Kozlowicz… - Infection and …, 2006 - Am Soc Microbiol
Francisella tularensis is the bacterial pathogen that causes tularemia in humans and a
number of animals. To date, there is no approved vaccine for this widespread and life …

Directed Screen of Francisella novicida Virulence Determinants Using Drosophila melanogaster

MK Åhlund, P Rydén, A Sjöstedt… - Infection and …, 2010 - Am Soc Microbiol
Francisella tularensis is a highly virulent, facultative intracellular human pathogen whose
virulence mechanisms are not well understood. Occasional outbreaks of tularemia and the …

Will the enigma of Francisella tularensis virulence soon be solved?

RW Titball, A Johansson, M Forsman - Trends in microbiology, 2003 - cell.com
Francisella tularensis is one of the most infectious bacterial pathogens known and is the
causative agent of the zoonotic disease tularemia. In spite of the importance of this pathogen …