The relation of Wnt/β-catenin signaling to osteoarthritis progression has been revealed with
little information on the underlying molecular mechanism. In this study we found …

T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are downstream
effectors of Wnt/β-catenin signaling, which has been implicated in the development and …

Objective The results of recent animal studies suggest that activation of Wnt/β‐catenin
signaling in articular chondrocytes might be a driving factor in the pathogenesis of …

Our previous study indicated that interleukin (IL)-1β induces expression of several Wnt
proteins in chondrocytes and causes chondrocyte dedifferentiation via the c-Jun/activator …

An association between Wnt/β-catenin signaling and MMP13 expression has been reported
but there has been little information about the underlying mechanism. Here, we investigated …

Facet joint osteoarthritis is common lumbar osteoarthritis characterized by facet joint
cartilage degeneration. However, the molecular basis of facet joint osteoarthritis remains …

Although the involvement of Wnt/β-catenin signaling pathway in the regulation of COX-2
expression has been suggested, the underlying molecular mechanisms are still unclear …

Objective Wnt signaling plays a pivotal role in skeletal development and in the control of
cartilage and bone turnover. We have recently shown that the secreted Wnt antagonist Wnt …

The aim of this study was to investigate the activation of the Wnt/β‐catenin pathway in
osteoarthritis and the role of low‐density lipoprotein receptor‐related protein 5 (LRP5) in …

Osteoarthritis (OA) constitutes a major health problem. Different signaling pathways are
involved that impair homeostasis, but the cross-talk between them (although well …