Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway

M Tian, P Ma, Y Zhang, Y Mi, D Fan - International Immunopharmacology, 2020 - Elsevier
Ginsenosides have a variety of pharmacological activities, including immunomodulatory,
antitumor and anti-inflammatory activities. However, the effect of Rk3 on ulcerative colitis has …

Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice

C Liu, J Wang, Y Yang, X Liu, Y Zhu, J Zou… - Biochemical …, 2018 - Elsevier
Previous studies reported that Ginsenoside Rd (Rd) had anti-inflammatory and anti-cancer
effects. However, the molecular mechanism underlying the inhibition effect of Rd on colitis in …

Ginsenoside Rk3 ameliorates obesity-induced colitis by regulating of intestinal flora and the TLR4/NF-κB signaling pathway in C57BL/6 mice

H Chen, H Yang, J Deng, D Fan - Journal of agricultural and food …, 2021 - ACS Publications
Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of
colorectal cancer. Dietary phytochemicals are considered to be an effective strategy for …

Ginsenoside Rg1 attenuates the inflammatory response in DSS-induced mice colitis

G Zhu, H Wang, T Wang, F Shi - International Immunopharmacology, 2017 - Elsevier
Ginsenoside Rg1 is a major active constituent of Panax ginseng and possesses anti-
inflammatory effects. It has been reported to have therapeutic effects on various diseases. In …

Suppression of MAPKs/NF-κB activation induces intestinal anti-inflammatory action of ginsenoside Rf in HT-29 and RAW264. 7 cells

S Ahn, MH Siddiqi, VC Aceituno, SY Simu… - Immunological …, 2016 - Taylor & Francis
This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in
inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the …

[HTML][HTML] Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-κB …

J Li, W Zhong, W Wang, S Hu, J Yuan, B Zhang, T Hu… - PloS one, 2014 - journals.plos.org
Phytogenic compounds with anti-oxidant and anti-inflammatory properties, such as
ginsenoside metabolite compound K (CK) or berberine (BBR), are currently discussed as …

[HTML][HTML] Ginsenoside Rg1 relieves experimental colitis by regulating balanced differentiation of Tfh/Treg cells

J Jin, Y Zhong, J Long, T Wu, Q Jiang, H Wang… - International …, 2021 - Elsevier
Inflammatory bowel disease (IBD) is typically characterized by the dysregulation of Tfh cell
differentiation. we sought to explore the potential mechanism of Ginsenoside Rg1 (G-Rg1) …

Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3/miR-214 signaling pathway

X Chen, T Xu, X Lv, J Zhang, S Liu - Journal of ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Ginseng is a valuable medicinal herb used in China for
the prevention and treatment of cancer, diabetes, cardiovascular diseases and other …

Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis

XL Yang, TK Guo, YH Wang, YH Huang, X Liu… - International …, 2012 - Elsevier
In this study, we investigated the effects and the protective mechanism of ginsenoside Rd
(GRd) which has been identified as one of the effective compounds from ginseng on …

Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20 (S)-protopanaxatriol in mice with TNBS-induced colitis

SY Lee, JJ Jeong, SH Eun, DH Kim - European Journal of Pharmacology, 2015 - Elsevier
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory
effect. In a preliminary study, it was observed that ginsenoside Rg1 was metabolized to 20 …