Levels of DNA adducts in Chinese hamster ovary (CHO) cells exposed to cis-
diamminedichloroplatinum (II)(cisplatin) for 24 h, have been shown to be 4-to 6-fold higher …

Some chemical carcinogens localize preferentially in mitochondrial DNA (mtDNA) when
compared with genomic DNA (gDNA). Here we compare the ability of cisplatin (cis …

Although there is evidence that the toxic effects of cis-diamminedichloroplatinum
(II)(cisplatin) include morphologically abnormal mitochondria, direct demonstrations of …

The purpose of this study was to determine whether cis-dichlorodiammineplatinum
(cisplatin) causes mitochondrial DNA (mtDNA) damage. A specific and sensitive method for …

High levels of cis-diamminedicholorplatinum II (cisplatin)-DNA adducts have previously
been observed at term in mitochondrial DNA (mtDNA) from organs of pregnant rats, and …

In this work, we measured the effects of pharmacological concentrations of cisplatin (cis-
diaminedichloroplatinum II) on mitochondrial function, cell viability, and DNA fragmentation …

The expression of intrinsic resistance to cisplatin in two lung cancer cell lines, one derived
from a small cell carcinoma (SW1271) and the other from an adenocarcinoma (A549) …

The persistence of platinum-DNA adducts was investigated using normal rats as well as
tissues from cancer patients receiving either cis-diamminedichloroplatinum (II)(cisplatin) or …

Cisplatin accumulates in mitochondria, which are a major target for this drug in cancer cells.
Thus alterations in mitochondrial function have been implicated in cancer cell resistance to …

Using methodology recently developed to assess gene-specific DNA repair, we have
demonstrated that it is possible not only to study mitochondrial DNA repair, but also directly …