Mitochondria are highly specialised organelles required for key cellular processes including
ATP production through cellular respiration and controlling cell death via apoptosis. Unlike …

Mitochondria are vital double-membrane organelles that act as a “powerhouse” inside the
cell and have essential roles to maintain cellular functions, eg, ATP production, iron-sulfur …

The mitochondrial genome encodes proteins essential for the oxidative phosphorylation
and, consequently, for proper mitochondrial function. Its localization and, possibly, structural …

Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

Mitochondria have their own genome, which is essential for proper oxidative
phosphorylation and hence for a large part of ATP production in a cell. Although …

The electron transport chain is the primary pathway by which a cell generates energy in the
form of ATP. Byproducts of this process produce reactive oxygen species that can cause …

The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic
cells to assemble a functional electron transport chain. This independently-maintained …

Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases
and alterations of the mitochondrial genome are assumed to be a result of its high …

Each mitochondrion consists of 16,569 base pairs which encodes 37 genes, all of which are
essential for normal mitochondrial function (Anderson et al., 1981). Each human cell …