The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule
cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of …

The brain does not operate like a typical computer—there is no central processing unit, there
are no separate memory banks, and performance degrades gracefully when individual …

Dendrites of individual neurons in the vertebrate central nervous system are contacted by
thousands of synaptic terminals relaying information about the environment. The …

In 1986, electron microscopy was used to reconstruct by hand the entire nervous system of a
roundworm, the nematode Caenorhabditis elegans. Since this landmark study, high …

Changing the strength of synapses is key to the adaptive modifications of what neuronal
circuits compute. Unsurprisingly, many different mechanisms have evolved to alter synaptic …

More than a century of dedicated research has resulted in what we now know, and what we
think we know, about synapses and neural circuits. This piece asks to what extent some of …

About 2 years ago when the journal gave us the opportunity to launch this Research Topic,
the three of us were excited by the rapid growth of cutting-edge imaging approaches now …

Although similar in molecular composition, synapses can exhibit strikingly distinct functional
transmitter release and plasticity characteristics. To determine whether ultrastructural …

Nanocolumns at the heart of the synapse | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Giant presynaptic terminal brain slice preparations have allowed intracellular recording of
electrical signals and molecular loading, elucidating cellular and molecular mechanisms …