Genetic correlations suggest a coexisting genetic predisposition to both low leptin levels and
risk for anorexia nervosa (AN). To investigate the causality and direction of these …

We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a
stringently defined phenotype. Analysis of phenotypic variability led to the identification of a …

Objective Although low weight is a key factor contributing to the high mortality in anorexia
nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia …

Epigenetic alterations are increasingly implicated in the pathophysiology of anorexia
nervosa (AN) but are as yet poorly understood. We investigated possible associations …

RATIONALE: Recently, we identified a genotype-by-smoking status interaction with serum
leptin levels in a sample of Mexican Americans. However, it is unknown whether this …

High physical activity (PA) in patients with anorexia nervosa (AN) is hypothesized to be, at
least in part, a consequence of hypoleptinemia. However, most studies on the association of …

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN)
for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) …

Background: A common single-nucleotide polymorphism identified in the 5′-untranslated
region of the leptin gene (LEP-2548 G/A polymorphism) may be associated with obesity, but …

Mutations in the leptin gene can result in profound obesity in both rodents and humans. 1–3
In humans, serum leptin levels correlate with body mass index 4 (BMI: kg m− 2). However, in …

Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a
crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) …