Chronic exposure to high glucose leads to diabetic nephropathy characterized by increased
mesangial matrix protein (eg, collagen) accumulation. Altered cell signaling and gene …

Aims/hypothesis Glomerular matrix accumulation is a hallmark of diabetic nephropathy.
Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix …

Although previous studies have demonstrated that diabetic nephropathy is attributable to
early extracellular matrix accumulation in glomerular mesangial cells, the molecular …

Diabetic nephropathy (DN) remains a major complication in both type 1 and type 2 diabetes.
Systemic administration of antitransforming growth factor‐β (TGF‐β) antibody has shown …

High glucose (HG) stimulates glomerular mesangial cell (MC) expression of extracellular
matrix, a process involving protein kinase C (PKC) isozymes and enhanced signaling by …

Activation of protein kinase C (PKC) is implicated as an important mechanism by which
diabetes causes vascular complications. We have recently shown that a PKC β inhibitor …

Insulin resistance has been associated with the progression of chronic kidney disease in
both diabetes and obesity. In order to determine the cellular mechanisms contributing to this …

Diabetic nephropathy is one of the most common microvascular complications of diabetes
mellitus and the leading cause of end-stage renal disease in developed countries. Current …

Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We have recently
shown that epidermal growth factor receptor (EGFR) transactivation mediates high glucose …

High ambient glucose exerts its injurious effects on renal cells through nonenzymatic and
enzymatic pathways, including altered signal transduction and upregulation of the …