Continuous changes in the length of smooth muscles require a highly organized
sarcolemmal structure. Yet, smooth muscle cells also adapt rapidly to altered environmental …

The arterial vessel wall is composed of a single layer of endothelial cells at the lumen and
multiple layers of smooth muscle cells (SMC) forming the media and then the adventitia. The …

We examined the relationship between growth arrest of smooth muscle cells and structural
changes in microfilament bundles, and also that between the structural changes and the …

Smooth muscle cells were isolated enzymatically from adult human arteries, grown in
primary culture in medium containing 10% whole blood serum, and studied by transmission …

The smooth muscle cell is the only cell type present in the media of the mammalian artery
(Pease and Paule, 1960; Karrer, 1961; Paule, 1963) and is therefore responsible for …

The process of differentiation of a cell involves its transformation from an initially totipotential
cell to the specialized form of the adult as occurs, for instance, in normal development. A …

Publisher Summary The late parental phase of mammalian blood-vessel development is a
complex and poorly understood process that involves dynamic changes in smooth-muscle …

Publisher Summary It is presently more and more accepted that phenotypic features of
smooth muscle cells and fibroblasts are not uniform. This plasticity or diversity is clear during …

In 1653, the English physician William Harvey published the first comprehensive study of
blood vessels, De Motu Cordis. 1 This classic treatise delineated the directions of blood flow …

Studies of bovine carotid artery smooth muscle cells, during long-term in vitro subcultivation
(up to 100 population doublings), have revealed phenotypic heterogeneity among cells, as …