In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

The development of many forms of intercellular communication was essential for the
evolution of multicellular organisms. The organization of cells into tissues and organs and …

Early observations showed a lack of growth control and terminal differentiation with a lack of
gap junctional intercellular communication (GJIC). Subsequent observations showed that …

To develop a strategy for efficacious intervention in order to prevent or treat various cancers,
one must understand the basic mechanism (s) by which various anticancer dietary factors …

Chemopreventive or chemotherapeutic agents have been those that either kill cancer cells
to a differential degree over the non‐cancer cells or those chemicals that either block the …

If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

Understanding the process of carcinogenesis will involve both the accumulation of many
scientific facts derived from molecular, biochemical, cellular, physiological, whole animal …

Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …

During the evolution of single-celled organisms to multicellular metazoans, a family of highly
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …