A series of cis-restricted 1, 5-disubstituted 1, 2, 3-triazole analogues of combretastatin A-4
(1) have been prepared. The triazole 12f, 2-methoxy-5-(1-(3, 4, 5-trimethoxyphenyl)-1H-1, 2 …

A series of cis-restricted 1, 4-and 1, 5-disubstituted 1, 2, 3-triazole analogs of combretastatin
A-4 (1) have been prepared. Cytotoxicity and tubulin inhibition studies showed that 2 …

To find new and better antivascular agents for cancer therapy, a series of combretastatin A4
(CA4) analogs were prepared from 1, 3-diaryl-2-nitroprop-1-enes (6–12) obtained in a two …

The synthesis, cytotoxicity, inhibition of tubulin polymerization data and anti-angiogenetic
effects of seven 1, 5-disubstituted 1, 2, 3-triazole analogs and two 1, 4-disubstituted 1, 2, 3 …

Novel combretastatin analogues bearing various five-membered heterocycles with
consecutive oxygen and nitrogen atoms, in place of the olefinic bridge of CA4, have been …

Abstract Twenty-six novel pyrazolo [3, 4-b] pyridine-bridged analogues of combretastatin A-4
possessing 3, 4, 5-trimethoxylphenyl groups, were synthesized and evaluated for their …

A series of cis restricted 1, 2, 4-triazole analogs of combretastatin A-4 (CA-4) were designed
and synthesized. The antiproliferative activity of these compounds was measured on …

Abstract Combretastatin A4 (CA4) is a natural product characterized by a powerful inhibition
of tubulin polymerization and a potential anticancer activity. However, therapeutic …

A series of cis-restricted 2-alkylthio-4-(2, 3, 4-trimethoxyphenyl)-5-aryl-thiazole analogues of
combretastatin A-4 were synthesized and investigated for inhibition of cell proliferation …

A series of combretastatin A-4 (CA-4) analogues have been prepared from (Z)-substituted
diarylacrylonitriles (1a-1p) obtained in a two-step synthesis from appropriate arylaldehydes …