The evolutionarily conserved TGF-β signalling pathway suppresses cell growth, yet loss of
function results in cancer phenotypes. Here, we evaluate loss of the TGF-β pathway signal …

The cell of origin of colon cancer is typically thought to be the resident somatic stem cells,
which are immortal and escape the continual cellular turnover characteristic of the intestinal …

Transforming growth factor beta (TGFβ) superfamily signaling is a prime inducer of epithelial-
mesenchymal transitions (EMT) that foster cancer cell invasion and metastasis, a major …

Colorectal cancer represents not only the second leading cause of cancer-related death in
Western world. The sequence of events that describes colorectal cancer development, the …

TGF-β signaling plays an essential role in colorectal cancer (CRC) progression. Patients
frequently suffer from mutations in the TGFBR2 gene or deletions of SMAD4. These …

Background/Aim: This study analysed threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr)
expression and investigated whether pSmad2/3L-Thr is related to the transition from human …

Abstract The Smad4+/E6sad mouse carries a null mutation in the endogenous Smad4 gene
resulting in serrated adenomas and mixed polyposis of the upper gastrointestinal (GI) tract …

Background: Colorectal cancer (CRC) is major cause of morbidity and mortality in cancer
patients worldwide and it ranks as the most common cancer in males and the third most …

The development of metastasis severely reduces the life expectancy of patients with
colorectal cancer (CRC). Although loss of SMAD4 is a key event in CRC progression, the …

Abstract About 10% to 30% of patients with colorectal cancer harbor either loss of or
missense mutations in SMAD4, a critical component of the TGFβ signaling pathway. The …