The second messenger molecule 3′ 5′-cyclic adenosine monophosphate (cAMP) imparts
several beneficial effects in lung diseases such as asthma, chronic obstructive pulmonary …

Cyclic 30, 50adenosine monophosphate (cAMP), a second messenger molecule with an
extensive range of antiinflammatory properties, also regulates disease related, pulmonary …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

Phosphodiesterases (PDEs) are important enzymes that hydrolyze the cyclic nucleotides
adenosine 3′ 5′-cyclic monophosphate (cAMP) and guanosine 3′ 5′-cyclic mono …

Highlights•COPD is irreversible and associates with pulmonary and extra-pulmonary
pathologies.•Current therapeutics acts as bronchodilators and/or anti-inflammatories.•When …

Cyclic AMP (cAMP) is a key second messenger in all cells. It is compartmentalized within
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …

The ubiquitous second messenger 3!, 5!-cAMP acts as a key player in the signaling
cascades that control many physiological and pathophysiological processes in the lung. The …

Introduction Phosphodiesterases (PDEs) are isoenzymes ubiquitously expressed in the
lungs where they catalyse cyclic adenosine monophosphate (cAMP) and cyclic guanosine …

Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are
currently used in the treatment of several chronic inflammatory disorders, including chronic …

Phosphodiesterases (PDE) belong to an important family of proteins that regulate the
intracellular levels of cyclic nucleotide second messengers. Targeting PDE with selective …