Role of Human N‐Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen‐Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary …
KJ Baldauf, RA Salazar‐González… - Environmental and …, 2020 - Wiley Online Library
Carcinogenic aromatic amines such as 4‐aminobiphenyl (ABP) and 2‐aminofluorene (AF)
require metabolic activation to form electrophilic intermediates that mutate DNA leading to …
require metabolic activation to form electrophilic intermediates that mutate DNA leading to …
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations
J Bendaly, MA Doll, LM Millner, KJ Metry… - Mutation Research …, 2009 - Elsevier
Aromatic amines such as 4-aminobiphenyl (ABP) require biotransformation to exert their
carcinogenic effects. Genetic polymorphisms in biotransformation enzymes such as N …
carcinogenic effects. Genetic polymorphisms in biotransformation enzymes such as N …
2-aminofluorene-DNA adduct levels in tumor-target and nontargetorgans of rapid and slow acetylator syrian hamsters congenic at the NAT2 locus
Y Feng, W Jiang, DW Hein - Toxicology and applied pharmacology, 1996 - Elsevier
DNA adduct formation is an important initial event in chemicalcarcinogenesis. Metabolic
activation and deactivation pathways are involved in aromatic amine carcinogenesis, and …
activation and deactivation pathways are involved in aromatic amine carcinogenesis, and …
N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis
DW Hein - Toxicology letters, 2000 - Elsevier
N-Acetyltransferases (EC 2.3. 1.5) are important in both the activation and deactivation of
aromatic and heterocyclic amine carcinogens. Two N-acetyltransferase isozymes (NAT1 and …
aromatic and heterocyclic amine carcinogens. Two N-acetyltransferase isozymes (NAT1 and …
Metabolic activation of aromatic and heterocyclicN-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases
DW Hein, TD Rustan, RJ Ferguson, MA Doll… - Archives of toxicology, 1994 - Springer
Recombinant human NAT1 and polymorphic NAT2 wild-type and mutant N-
acetyltransferases (encoded by NAT2 alleles with mutations at 282/857, 191, 282/590 …
acetyltransferases (encoded by NAT2 alleles with mutations at 282/857, 191, 282/590 …
[HTML][HTML] 560G> A (rs4986782)(R187Q) Single nucleotide polymorphism in arylamine N-Acetyltransferase 1 increases affinity for the aromatic amine carcinogens 4 …
MA Doll, DW Hein - Frontiers in Pharmacology, 2022 - frontiersin.org
Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine
carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O …
carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O …
Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4′-methylene bis (2-chloroaniline) biotransformation
Abstract Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the acetylation of
arylamine carcinogens. Single nucleotide polymorphisms in the NAT2 coding exon present …
arylamine carcinogens. Single nucleotide polymorphisms in the NAT2 coding exon present …
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2‐amino‐1‐methyl‐6 …
AJ Fretland, US Devanaboyina… - … of Biochemical and …, 2001 - Wiley Online Library
Abstract N‐acetyltransferases (EC 2.3. 1.5) catalyze O‐acetylation of heterocyclic amine
carcinogens to DNA‐reactive electrophiles that bind and mutate DNA. An acetylation …
carcinogens to DNA‐reactive electrophiles that bind and mutate DNA. An acetylation …
Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N …
MR Habil, RA Salazar-González, MA Doll… - Archives of toxicology, 2022 - Springer
Abstract β-naphthylamine (BNA) is an important aromatic amine carcinogen. Current
exposures derive primarily from cigarette smoking including e-cigarettes. Occupational and …
exposures derive primarily from cigarette smoking including e-cigarettes. Occupational and …
The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic …
DW Hein, RA Salazar-González, MA Doll, Y Zang - Archives of Toxicology, 2023 - Springer
Abstract Human N-acetyltransferase 2 (NAT2) is subject to genetic polymorphism in human
populations. In addition to the reference NAT2* 4 allele, two genetic variant alleles (NAT2 …
populations. In addition to the reference NAT2* 4 allele, two genetic variant alleles (NAT2 …