The calcium-sensing receptor (CaR) belongs to the G protein-coupled receptor superfamily,
with a characteristic structure consisting of seven transmembrane helices, an intracellular C …

The calcium (Ca2+)-sensing receptor (CaR) belongs to family C of the G-protein coupled
receptors (GPCRs). The receptor is activated by physiological levels of Ca2+ (and Mg2+) …

The extracellular Ca 2+-sensing receptor (CaR) is an unusual member of the diverse
superfamily of seven-transmembrane domain G-protein-coupled receptors. Originally …

The calcium‐sensing receptor (CaR) is the key controller of extracellular calcium (Ca2+ o)
homeostasis via its regulation of parathyroid hormone (PTH) secretion and renal Ca2+ …

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled
receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It …

Calcium (Ca2+) has long been recognized as a physiologically indispensable ion owing to
its numerous intra-and extracellular roles. More recently, it has become apparent that …

The recent cloning of an extracellular calcium (Ca2+ o)-sensing receptor (CaR) from
parathyroid, kidney and other cell types has clarified the mechanisms through which Ca2+ o …

The calcium-sensing receptor (CaR) belongs to family C of the G-protein-coupled receptor
superfamily. To date 14 activating mutations in CaR showing increased sensitivity to Ca 2+ …

Abstract The extracellular calcium (Ca 2+ _o)-sensing receptor (CaR) enables the
parathyroid glands and other CaR-expressing cells to sense alterations in the level of Ca 2+ …

The calcium-sensing receptor (CaR) is activated by small changes in the ionic extracellular
calcium concentration (Ca o) within the physiological range, allowing the parathyroid gland …