Classic studies over the last two decades have made virus-induced activation of the
mammalian interferon-b (ifnb) gene a prototype of eukaryotic gene regulation [1–6]. Indeed …

The type I interferon (IFN) α and β promoters have been a leading paradigm of virus-
activated transcriptional regulation for more than two decades, and have contributed …

Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell
survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in …

Production of type I interferons (IFN-I) is a crucial innate immune mechanism against viral
infections. IFN-I induction is subject to negative regulation by both viral and cellular factors …

Production of type I interferons (IFNs; prominently, IFN-α/β) following virus infection is a
pivotal antiviral innate immune response in higher vertebrates. The synthesis of IFN-β …

RNA virus infection results in expression of type 1 IFNs, especially IFN-α/β, which play a
crucial role in host antivirus responses. Type 1 IFNs are induced in a cell type-specific …

NF-κB is known to exert its antiviral innate immune response via the IFN-β-induced Janus
kinase/signal transducers and activators of transcription pathway. However, our current …

Type I interferon-α/β play an essential role in immunity to viruses. While interferon-β has
been used as a model of a complex promoter, many of the signalling pathways leading to …

Precise control of inflammatory gene expression is critical for effective host defense without
excessive tissue damage. The principal regulator of inflammatory gene expression is …

Type III interferons (IFNs; IFN-λ) are antiviral cytokines with type I IFN-like biological
functions, including antiviral activity. In this article we review the literature on IFN-λ …