Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.
However, the origin of excessive damages caused by SARS-CoV-2 remains largely …

COVID-19 is one of the most impactful pandemics in recorded history. As such, the
identification of inhibitory drugs against its etiological agent, SARS-CoV-2, is of utmost …

Key points We report a novel method for the transient expression of SARS‐CoV‐2 envelope
(E) protein in intracellular organelles and the plasma membrane of mammalian cells and …

The outbreak of COVID-19 across the world has posed unprecedented and global
challenges on multiple fronts. Most of the vaccine and drug development has focused on the …

Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of
COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface …

Coronavirus disease 2019 is a major threat to public health globally. Though its
pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has …

Coronavirus E protein is a small membrane protein found in the virus envelope. Different
coronavirus E proteins share striking biochemical and functional similarities, but sequence …

Emerging evidence suggests that endothelial activation plays a central role in the
pathogenesis of acute respiratory distress syndrome (ARDS) and multiorgan failure in …

Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …

Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5–10% of
cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of …