Until recently, the bulk of research on the human reward system was focused on studying
the dopaminergic and opioid neurotransmitter systems. However, extending the initial data …

Anhedonia, as a failure to experience rewarding stimuli, is a key characteristic of many
psychiatric disorders including depression and schizophrenia. Investigations on the …

Reward function is increasingly considered to be an important aspect of affective disorders
such as depression and bipolar disorder. Conceptual models of affective disorders …

Reward related behaviour is linked to dopaminergic neurotransmission. Our aim was to gain
insight into dopaminergic involvement in the human reward system. Combining functional …

Experimental work in animals has identified numerous neural structures involved in reward
processing and reward-dependent learning. Until recently, this work provided the primary …

Abstract Serotonin (5‐HT) has been implicated in the aetiology of a number of psychiatric
conditions, including depression, anxiety and antisocial personality disorder. The …

Objective: A role for aberrant reward processing in the pathogenesis of depression has long
been proposed. However, no review has yet examined its role in depression by integrating …

Functional magnetic resonance imaging (fMRI) is a noninvasive tool used to probe cognitive
and affective processes. Although fMRI provides indirect measures of neural activity, the …

Scientific interest in how the brain processes reward has burgeoned during the past 50
years since the discovery that rats will do tasks such as pressing a lever to obtain electrical …

The dopaminergic mechanisms that control reward-motivated behavior are the subject of
intense study, but it is yet unclear how, in humans, neural activity in mesolimbic reward …